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Guided by the bioinformatics analysis, our study further revealed the mechanisms of the diagnosis and prognosis of cancers

In addition, hepatic factors and the signaling proteins secreted by the liver can reach the eye and cause oxidative stress and inflammation

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Existing drugs lack precision in targeting specific tissues

It can be seen that the inhibition of GPX4, the depletion of glutathione and the increase of lipoxygenase activity promote the accumulation of polyunsaturated fatty acids and the production of fatty acid-free radicals, thereby inducing the occurrence of cell ferroptosis, cause tissue damage, and further aggravate pathological processes including diabetes, periventricular leukomalacia, acute kidney disease, cancer, and other diseases (Otasevic et al., 2021)