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Description

Chloramphenicol (Chloromycetin): metabolized by cytochrome P450 to an alkylating metabolite that inactivates cytochrome P450 Other inactivators: Mechanism of Action: -- targeting the heme moiety: Steroids: Ethinyl estradiol (Estinyl) Norethindrone (Aygestin) Spironolactone (Aldactone) Others: Propylthiouracil Ethchlorvynol (Placidyl) Overview: Phase II reactions involve non-microsomal enzymes Reaction types: Conjugation Hydrolysis Oxidation Reduction Location (non-microsomal enzymes): primarily hepatic (liver)

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