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2D), validating the findings obtained using the untargeted LC-MS/MS acquisition

Upon activation, free radicals such as nitric oxide (NO) and superoxide are released, which elevates oxidative stress contributing to pathogen elimination and local tissue damage ( Migraine Pathogenesis: Role of Oxidative Stress, Neuroinflammation, and Mitochondrial Dysfunction Migraine is defined as a neurovascular disorder involving cortical spreading depression (CSD), neurogenic inflammation, and dysfunction in cranial vascular contractility ( Oxidative Stress Oxidative stress role in migraine pathogenesis is emphasized by multiple studies

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Mol Aspects Med 32(46):305315 Ramrez-Rodrguez G, Klempin F, Babu H, Bentez-King G, Kempermann G (2009) Melatonin modulates cell survival of new neurons in the hippocampus of adult mice

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