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When to Adjust Dosing Increase dose if: After 4-6 weeks at current dose, no measurable body composition changes occur, youre tolerating current dose without side effects, youre below the upper clinical range (1 mg daily), and your physician approves escalation based on comprehensive assessment

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As discussed ( earlier, to the extent the data shows that there would be more than a limited impact on the relative weights initially, which we do not believe will be the case, we intend to provide an opportunity for additional public input and will continue to provide impact analyses of changes in the MS-DRG relative weights in the annual IPPS rulemaking