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When artemisinin consumes heme 25,26 (or iron 27 ) and produces free radicals or heme-artemisinin adducts to inhibit heme crystallization 28 , even accelerating the breakdown of hemozoin 5 , it simultaneously inevitably interferes the normal formation and degradation of hemozoin, uses up iron by forming iron-artemisinin within the parasites, interferes or interrupts the transport and utilization of iron, thereby finally leading to death of the malaria parasites

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doi: 10.4238/gmr.15027558

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis

For example, based on its strong antibacterial activity, biodegradability and low toxicity, -PL has been generally recognized as a safe (GRAS No.000135) food preservative for routinely using in Japan, Korea, USA, China and other countries[15, 16]