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These build upon similar work using ex vivo organotypic slices and 2D cancer cell co-culture [14, 163]

Indeed, it has previously been demonstrated that in the SOD1 WT the loss of structural Zn 2+ , a common attribute of SOD1 misfolding 34 , increases accessibility of the active site to substrates other than superoxide and enhances oxidizing ability of the catalytic copper, thus facilitating ROS production 35,36

Neutrophil extracellular traps confine Pseudomonas aeruginosa ocular biofilms and restrict brain invasion

Detchaporn P., Kukongviriyapan U., Prawan A., Jetsrisuparb A., Greenwald S

An evaluation of the role of TDLN in PD-1/PD-L1 checkpoint blockade therapy in two mouse tumor models reveals that immune checkpoint treatment induces CD8+ T cell accumulation in the tumor-draining but not in non-draining LNs (210)abrogated checkpoint therapy, suggesting that TDLNs function as sites of T cell invigoration required for PD-1/PD-L1 checkpoint blockade therapy (211, 212)