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For example, the polynucleotide may be partially phosphorothioate-linked, e.g., phosphorothioate linkages may alternate with phosphodiester linkages

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[44] Maternal vitamin B12 deficiency during pregnancy can lead to neural tube defects, impaired brain development, preterm birth, and low birth weight

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For references and more information , see the section on homocysteine in the Vitamin B 12 article

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Mol Cell Biol (2002) 22:761421

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