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Side effects : nausea mucosal ulcers leukopenia, anemia, GI ulcerations, alopecia (due to inhibition of cell proliferation) dose-related HEPATOTOXICITY unwanted side effects of methotrexate are (see text box) reduced with use of leucovorin or folic acid coadministration Folic Acid Is Commonly Prescribed Alongside Low Dose MTX Folic acid therapy is almost invariably prescribed alongside low-dose methotrexate in the treatment of rheumatoid arthritis (Friedman & Cronstein, 2019)

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The use of combination therapy can be considered in patients with peripheral involvement, or with other manifestations such as uveitis or IBD

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When CA and LP-GEL were applied together, skin wound healing accelerated, and inflammatory reaction and melanosis were inhibited (Su et al., 2024)