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Although Rosuvastatin is safe and effective for many people, it does cause an extensive amount of adverse effects, including the following: Muscle weakness, muscle cramps, stiffness and spasms (Myopathyaffects muscles that connect to your bones) Muscle pain and/or soreness (Myalgias) Join pain (Arthralgia) Cognitive impairment Headache Cold-like symptoms, including sore throat, stuffy nose, and/or sneezing Insomnia Nausea Heartburn Abdominal pain Indigestion Constipation Weakness Do not abruptly discontinue taking rosuvastatin if you are encountering any negative side effects