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Because decreases in FEV 1 could be due to either bronchoconstriction and/or mucus obstruction, it is possible that dual blockade of NK1 and NK2 receptors in asthmatics augmented mucus secretion and/or bronchoconstriction to allergen

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Notably, ablation of OXPHOS by simultaneous inhibition of complex I, III and V of the respiratory chain reduced the capacity of human CD4 + T cells to produce IFN and TNF (Extended Data Fig

SLC7A11 overexpression inhibits pyroptosis by ensuring robust GSH levels and reduced ROS 62 , whereas inhibition of glutamine uptake causes decreased GSH and increased ROS, leading to GSDME-dependent pyroptosis in non-small cell lung cancer (NSCLC) cells 63