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Results Metabolite profiling in the motor cortex with TDP-43 pathology reveals energy deficiency and oxidative stress We previously identified major mitochondrial problems, especially within the corticospinal motor neurons (CSMN) of prpTDP-43 A315T mice 16 (Fig

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The landmark SURMOUNT-1 trial demonstrated that participants receiving the highest dose of tirzepatide lost up to 22.5% of their total body weight over 72 weeks

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