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Other signs may include shortness of breath, pale skin, stomach problems, such as constipation, diarrhea or gas, or nerve problems, like muscle weakness or tingling in fingers or toes. Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says

While efficacy matters, the tolerability and adverse effect profile often determines whether a treatment is suitable for long-term use

Vitamin E is as a fat-soluble intracellular antioxidant, involved in stabilising unsaturated fatty acids, thereby preventing toxic lipo-peroxides formation

PMC 2773890

This format suits clinics handling frequent injections throughout daily medical operations