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J Mol Biol 292: 10031016

The frequency directly impacts the steady-state concentration of the compound in the system

Take collagen, for instance

J Immunol (2009) 182:690714.10.4049/jimmunol.0803533 143 HartmannSKyewskiBSonnenburgBLuciusR

Recent studies identified a novel copper-dependent form of cell death called cuproptosis, which is distinct from all other known pathways underlying cell death