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84,85 In a crossover study of healthy dogs taking the steroid prednisolone, SAMe supplementation at 10 mg/kg body weight twice daily for 42 days was found to reduce blood markers of liver oxidative damage, although the dogs still developed signs of steroid-induced liver disease

On-demand (2 vials): 6 mL 1 10 mL bottle 16-week daily (10 vials): 30 mL 3 10 mL bottles Alcohol Swabs: One for the vial stopper + one for the injection site each use

The upregulated Pt transporters [e.g., organic cation transporters (OCTs), multidrug and toxin extrusion proteins (MATEs), and copper transporters 1/2 (Ctr1/2)] in DGR increase the accumulation of Pt drugs in peripheral nerves as the first step to induce PIPN (Sprowl et al., 2013

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2.4 Administration of NASCOBAL with Other Therapy NASCOBAL should be administered with other therapy(ies) in: Patients with concurrent folate and vitamin B12 deficiency:Administer folic acid in addition to NASCOBAL Patients with concurrent iron and vitamin B12 deficiency:Administer iron in addition to NASCOBAL Patients with correctible causes of vitamin B12 deficiency:Consider measures to treat the underlying condition associated with vitamin B12 deficiency in addition to treatment with NASCOBAL 3