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3 Pharmacological profile 3.1 Antitumor activity Cancer progression is driven by dysregulated signaling pathways, including hyperactivation of oncogenes and inactivation of tumor suppressors, promoting uncontrolled cell proliferation, resistance to apoptosis, and metastatic spread (Tan et al., 2016), while concurrently modulating MAPK/ERK (Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase) and PI3K/AKT (Phosphatidylinositol 3-Kinase/Krotein Kinase B) pathways to induce DNA damage responses

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Large brains in autism: the challenge of pervasive abnormality

Pooyandjoo M, et al

Those patients that are coinfected with Onchocerca and Loa loa react with significant inflammation when treated with ivermectin, resulting in severe neurologic symptoms including coma, encephalitis, retinal hemorrhages, and membranous glomerulonephritis