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Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease

For any in-vivo animal research conducted in the United Kingdom, full compliance with the Animals (Scientific Procedures) Act 1986 (ASPA) is mandatory, requiring valid Home Office licences and institutional ethical approval

Additionally, it has been found to inhibit cartilage degradation caused by inflammatory mediators like prostaglandin E2 (PGE2) and interleukin 1 beta (IL1)