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Furthermore, another study found increased basal cortisol levels in the preterm septic neonates compared to controls, together with significant HPA axis dysfunction and an inverse relationship between blood pressure and cortisol levels, suggesting cardiovascular tissue glucocorticoid resistance (321)

Other factors that may increase the selenium requirement include diets with low concentrations of protein (especially sulfur-containing amino acids), diets with an excess of selenium antagonistic compounds, and possibly genetic influences on selenium metabolism