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The presence of CD206+/CD163+ M2 macrophages at the site of renal injury is associated with the severity of fibrosis ( Injured renal epithelial cells produce DAMPs and pathogen-associated molecular patterns (PAMPs) ( Interestingly, increased migration of macrophages around tubular epithelial cells that have been damaged by lipotoxicity has been described as a hallmark of diabetic nephropathy ( Increased expression of CD74 has been found in podocytes and parietal epithelial cells ( Figure 2 illustrates the sequential role of macrophages in the progression of CKD, emphasizing key stages, cytokine interactions, and molecular pathways

139 , 370372, doi: 10.1164/ajrccm/139.2.370 (1989)

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A third step in tumor progression is the mutational inactivation of the transforming growth factor- (TGF- ) signaling pathway, which facilitates adenoma transition to high-grade dysplasia or carcinoma and also inactivates SMAD4

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