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Rapamycin may be beneficial in the early stages of AD, but it aggravates AD pathology as the lysosomal degradative capacity of the brain deteriorates

It further dissects the role of lipid metabolism in reshaping the functions of T cells, B cells, macrophages, and dendritic cells, and delineates its organ-specific dysregulation in various ADs (e.g., synovium, skin, central nervous system, gut)

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