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In conclusion, though two small human studies found no significant effect of selenium supplementation on the structure of the adult gut microbiota, most animal studies have shown that different forms of selenium supplements significantly regulate the structure of gut microbiota in animals

Johansson HJ, El-Andaloussi S, Holm T, Me M, Jnes J, Maimets T, et al

As the field develops, direct measurement of circulating MOTS-c may become a useful biomarker for guiding dose adjustments, similar to how IGF-1 is used to monitor growth hormone or testosterone levels guide TRT dosing

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