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The imbalance between the production of reactive oxygen species (ROS) and the availability of antioxidants or free radical scavengers can cause oxidative stress, and that further activates an abundance of transcription factors and pro-inflammatory genes such as NF-B, p53, HIF-1, PPAR-, -catenin/Wnt, and Nrf2 [5,6,7]

Abstract Copper, an essential trace element for the human body, plays a key role in energy metabolism, mitochondrial respiration, redox reactions, and neural signal transmission

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As a neuromodulator, glutathione even binds to and/or activates several types of receptors in brain, potentially making it a neurotransmitter

Samples exhibiting atypical clustering patterns in quality control assessments were excluded from further analysis