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Dose-adjusted DOACs have been primarily examined in randomized controlled trials (RCTs) to prevent stroke in specific subgroups of patients with AFib, such as patients with advanced age, low body weight, renal dysfunction, and/or drug interactions

The formation of 5-methylTHF depends on N 5,10 -methylenetetrahydrofolate reductase (MTHFR), which catalyzes the reduction of N 5,10 -methylenetetrahydrofolate (5, 10-methyleneTHF) (Fig

For adipose-derived MSCs (AD-MSCs), hypoxia can promote migration (Wan et al., 2016

Cell vitality measurements (WST1 assays) of primary (a, c) endothelial cells or (b, d) astrocytes after exposure to vehicle (0, white) or to increasing concentrations of cuprizone (50500 M, red) for 24 h (a, b) or with 250 M cuprizone for 72 h (c, d) ( N = 5 per condition)

As recognized, overcorrection in hyponatremia management depends on crucial factors, including the rapid sodium level increase post-treatment and patients' susceptibility to serum sodium rise due to autocorrection, like ADH suppression after volume repletion in hypovolemic situations, causing significant diuresis