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Herein, we review the emerging data regarding the aetiology and features of LCINS, particularly the genetic and environmental underpinnings of this disease as well as their implications for treatment

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This catalyst effect, supported by findings that initial E-cigarette use predicts future smoking and that product initiation correlates with increased susceptibility to other products, means that pouch use might not only establish nicotine dependence but could also serve as a gateway to initiating or maintaining the use of other, potentially more harmful, products like cigarettes or E-cigarettes (30, 31)

Researchers used blood samples collected from 16,000 people to analyze the DNA methylation sites across the human genome

Research electronic data capture (REDCap)a metadata-driven methodology and workflow process for providing translational research informatics support