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Cocaine binds with high affinity to the norepinephrine transporter (NET) on the presynaptic nerve terminal (Kd 0.3 M), acting as a transmembrane physical plug that inhibits reuptake of norepinephrine

Bennett CF, Spector DL, Yeoman LC (1986) Nonhistone protein BA is a glutathione S-transferase localized to interchromatinic regions of the cell nucleus

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Similarly, standard oral glutathione is often broken down by stomach acid and digestive enzymes before it can ever be absorbed