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Optimization of IMRT Plans Based on Biologically Equivalent Uniform Dose

Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways

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One reason may be that A is secreted as an antimicrobial agent 12 but alternatively it may be secreted in response to infection because of pathway activation for the processing of the APP protein into A which is then secreted

Not sure if you know this but it's worth mentioning that if you have any neurological symptoms when you were diagnosed, the B12 regime (according to all guidelines) is six loading doses of 1mg B12 and then 1mg injections every other day until no further improvement (for some people this takes many months)