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Nature , 432(7016), 640645

11 Experimental GerontologyRodent studies describing melatonin/circadian restoration and lifespan-related effects of pineal peptides

We provide evidence that GDF11 upregulates Deptor, an inhibitor of mTOR, and downregulates S6K1 activity, a downstream target of mTOR

For this reason, we are utilizing 15 different iPSC lines in these studies to ensure reproducibility of the two differentiation protocols across multiple lines