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Medications that interfere with folate metabolism, such as sulfadiazine or pyrimethamine used in EPM treatment, can also reduce availability, making supplementation beneficial in some cases

Bulletin of Environmental Contamination and Toxicology 2007;78:330-334

Patients were reviewed at least every 6 months over the first 36 months of the trial to assess for the development of LRE including liver related death, hepatocellular carcinoma, large varices requiring therapy, ascites, spontaneous bacterial peritonitis and encephalopathy

Listening to Your Body While the morning is generally recommended, everyones biology is slightly different