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Proteomic studies corroborate these findings, reporting decreased levels of proteins involved in mitochondrial energetics, ETC function, redox balance and stress response pathways in IBD mucosa [254, 255] (Fig

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Such high micromolar GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77

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