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After 30 days of oral administration to 5-month-old transgenic mice, these mycelia were able to attenuate cerebral A plaque burden, prevent recruitment and activation of plaque-associated microglia and astrocytes, promote the expression of IDE, increase the NGF-to-NGF precursor (proNGF) ratio, and enhance the proliferation of neuron progenitors and the number of newly born neurons in the dentate gyrus region [43]

Harnessing computational approaches for RNA-targeted drug discovery

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The glutamic acid derived from Gln breakdown in the TCA cycle induces structural and functional changes in mitochondria, including depolarization of the mitochondrial membrane potential and reduced activity of the mitochondrial electron transfer chain