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Folate metabolism can be impaired by 2 different polymorphisms of MTHFR: MTHFR 677CT + MTHFR 1298AC = lowest MTHFR activity MTHFR 677C/T is associated with a significant decrease of MTHFR enzymatic activity that can reach up to 70% in homozygous (MTHFR T/T), while the heterozygous (C/T) genotype has a 35% decreased activity

While overdosing through food sources is nearly impossible, taking large doses via supplements or IV therapy can carry some risks

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For those considering 5-amino-1-mq dosage protocols, body weight calculations often guide initial dosing decisions