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However, compared to other neurotransmitter systems, its in-vivo assessments pose several challenges ( in vivo technique and having an excellent safety profile ( Due to conformational issues and the difficulty of utilizing brain-penetrating ligands for amino acid receptors, there has been little advance in developing radiotracers for ionotropic glutamate receptors, with the exception of the NMDA receptor (GluN2B subunit ligand)

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When the body does not absorb enough vitamins, minerals, and antioxidants from the food, nutritional deficiencies develop