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doi: 10.3892/etm.2019.7981 102 ParkJ-EJeongG-HLeeI-KYoonY-RLiuK-HGuNet al

Adults that declined (vs enrolled) were temporally closer to time of LT (21.9 mo vs 38.9 mo, p =0.049), more frequently had comorbid psychiatric diagnosis (36.4 vs 7.1%, p =0.006), and history post-LT of slip or relapse (39.1 vs 14.6%, p =0.01)

The authors suggest that 17-estradiol may still upregulate PKC isozymes differently, that is increasing some while decreasing others resulting in little overall change to PKC activity [54], however future studies are needed to confirm this assertion [54]