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doi: 10.1016/S0140-6736(23)01478-2 33

2025;45:e70006

784,785 Pre-stroke exercise intervention alleviates stroke-induced ferroptosis by reducing the production of LPO, upregulating GPX4 and SLC7A11, and downregulating ACSL4, thereby reducing the size of cerebral infarction and improving the neurological function of ischemic stroke rats

Research has indicated that biomarkers linked to oxidative stress, such as urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), nitrite (NO 2 ), nitrate (NO 3 ), and biopyrrin, are significantly increased in AD patients (2224)