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Emerging studies from our group and others uncovered oxalate metabolism commonly dysregulated in MASLD and cardiovascular disease 12,15,24,25,26,65

A GPR56-targeted antibody-drug conjugate (ADC) in preclinical study utilizing duocarmycin SA, a DNA minor-groove alkylating agent, demonstrated target-dependent tumor growth inhibition in CRC xenografts and patient-derived organoids with acceptable tolerability (90, 93)

The binding affinity of HOP1 to LET7 TPR is higher than that between LET7 TPR and LET7 PPase , supporting the idea that HOP1 competitively displaces LET7 PPase from LET7 TPR , thereby relieving autoinhibition and enhancing the catalytic activity

Similarly, contractile force can be increased by treatments that decrease cGMP levels (e.g