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Dysregulated NAD + metabolism accompanies increased glycolytic activity, further accentuated by the upregulation of glucose/lactate transporters and enzymes such as glucose transporter (GLUT)-1/3, MCT1/4 and LDH in response to oncogenic drivers such as HIF-1, PI3K/AKT/mTOR and c-Myc 16

Further studies have shown that curcumin could induce caspase-3-dependent apoptosis and autophagy, inhibit NF-B activation, and protect macrophages from P19-induced apoptosis to kill intracellular Mtb in macrophages (Zhang et al., 2014

Proteomic analysis revealed andrographolide induces expression of the glutathi

Similarly, role of lycopene as an antioxidant was assessed in streptozotocin (STZ) induced diabetic rats, In this regard, 6 female rats received 10 mg/kg body weight lycopene once a day for three weeks