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It has the longest safety record and the most supporting evidence

Nerve damage happens when the provider places the needle incorrectly or at an inappropriate angle, causing numbness, tingling, or pain

Call your health care provider immediately if you are experiencing any signs of an allergic reaction: skin rash, itching or hives, swelling of the face, lips, or tongue, blue tint to skin, chest tightness, pain, difficulty breathing, wheezing, dizziness, red, swollen painful area on the leg

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In contrast, PPI disrupts the growth of hydroxyapatite crystals and inhibits bone mineralization