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One such example are mice with a deletion of the DNA repair factor (Ercc1) in hematopoietic cells only (Yousefzadeh et al, 2021)

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doi: 10.1016/j.ymthe.2024.10.025 62 LuYZhuJZhangYLiWXiongYFanYet al

This places the 2' hydroxyl on the last nucleotide in the active site, where ATP (colored white) and the amino acid (not present in this structure) are bound

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