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PLoS ONE 13 , e0191912e0191912 (2018)

The absence of mTORC2 leads to a decrease in the levels of TCA cycle intermediates, especially -KG

When excessive moisture is present in high-humidity geographic areas or water-damaged buildings, the growth of these biological agents in damp environments leads to the production of spores, cells, fragments, and volatile organic compounds, which have been linked to a wide range of health hazards

In addition, aberrant activation of NRF2 also serves to increase the production of building blocks to sustain uncontrolled proliferation in cancer