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Probiotic fermentation technology (PFT) has been reported to improve insulin signalling by modulating the gut microbiota, upregulating insulin receptor expression and activating PI3K/Akt signalling, followed by inhibition of GSK-3 and mTOR signalling, which leads to the downregulation of over-phosphorylated tau proteins in order to halt the development of memory and cognitive impairment (129)

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96 Macrophages Among the non-parenchymal cells involved in liver regeneration, the role of macrophages has been well highlighted in clinical patients and mouse models

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Folate, B12, B6, iron and copper anaemia can lead to tiredness and lethargy