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Ample evidence exists that all these conditionscardiovascular risk factors, metabolic syndrome, insulin resistance, increased oxidative stress and systemic inflammation are great promoters of CVD and CVD-related mortality

Currently, interventions specifically targeting inflammatory mediators to slow DKD progression are limited

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

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Fewer amino acids mean fewer potential degradation sites and simpler folding that is more resistant to thermal denaturation