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Interestingly, certain MPs may be metabolically processed by the human gut microbiota without causing detrimental alterations

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doi: 10.1038/s41401-022-00902-w 137

The activation of the PI3K/Akt pathway can also promote an increase in HIF-1 level, which upregulates VEGF expression, and VEGF then activates the PI3K/Akt pathway through the VEGFR2 receptor on the cell membrane, thus amplifying the protective effect on neurovascular units (Karar and Maity, 2011