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impaired mitochondrial buffering leads to matrix Ca 2+ overload, m collapse, mPTP opening, and intrinsic apoptosis (Matuz-Mares et al., 2022)

In breast cancer, transcription factor AP-2 gamma (TFAP2C) is an important transcription factor that regulates estrogen receptor-alpha (ER) and c-ErbB2/HER2 (Her2), which are involved in the establishment of the gene expression pattern observed in different clinical phenotypes of breast cancer [79, 80]