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Theoretically, the intracellular assimilation of folic acid via dihydrofolate reductase might enhance thymidylate synthetase by bypassing the methylfolate trap, thereby allowing cellular proliferation to progress temporarily

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Lacking DNA methylation to activate histone modifications such as reduced methylation of Lys4 of histone H3 (H3K4me) are characters of actively transcribed genes (71)