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This binding depends on the intact N-terminal hexapeptide sequencemechanical shear stress from shaking or direct powder impact can break peptide bonds in that sequence, reducing receptor binding affinity by 1540%

Epithalon is not FDA-approved for the indications described on this page

The main advantage of melatonin antioxidant therapy is its relatively adequate safety, as confirmed in short-term studies

doi: 10.1111/imj.12522 29 SechiGSerraA