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After initial lytic replication, the hallmark of herpesvirus infection is the establishment of latency during which genome maintenance is ensured but productive replication is suppressed

Human NLRP3 inflammasome activation is Nox1-4 independent

Marseglia, L., DAngelo, G., Manti, S., Reiter, R

It reveals that selective ubiquitin-proteasomal degradation of PHGDH may be a more viable therapeutic strategy compared to PHGDH enzyme inhibitors

Their results revealed that decreasing NNMT expression in primary hepatocytes led to a reduction in the expression of phosphoenolpyruvate carboxykinase 1 (Pck1) and glucose-6-phosphatase (G6pc), resulting in decreased glucose output