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Zigouras, S., et al., Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats

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Immediate effect on the blood vessels presentation upon fistula creation was assessed considering the point immediately before therapy (point 0 as 100%) and scoring the vessel presentation (recorded filled/appearance or emptied/disappearance (camera attached to a USB microscope (Veho discovery VMS-004 deluxe))) at the 30 mm duodenum segment aboral and oral to the fistula, arcade vessels arising from the superior anterior pancreaticoduodenal vein and artery on the ventral duodenum side, and the corresponding colon segment, after 3, 6, 9, 12, and 15 minutes

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A successful example of the former approach is aflibercept (Eylea), also known as VEGF-trap [15]