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Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation

Ligand-dependent TLR4 activation (e.g., by advanced glycation end-products or LPS), initiates NF-B-driven pro-inflammatory and fibrotic cascades and NLRP3 inflammasome priming

[DOI] [PubMed] [Google Scholar] 20.Suzuki Y.J., Tsuchiya M., Packer L

[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Hu L., Chen W., Tian F., Yuan C., Wang H., Yue H

When acetyl groups break off the fatty acid chains, the acetyl groups then non-enzymatically combine to form ketone bodies, acetoacetic acid, beta-hydroxybutyric acid and acetone, all of which increase the acidity of the blood