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The studies were short, involved small numbers and often provided limited information about safety monitoring

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This article is written for readers who want a credible, mechanism-first frameworknot a protocol collage

Diagnostically specific, illness-related changes as well as outcome-associated plastic response are observed as illustrated for two pediatric populations, childhood-onset schizophrenia and attention-deficit/hyperactivity disorder, conditions which may be, in part, disorders of brain plasticity