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So even though they are no longer formally restricted by Category 2, the affirmative basis to compound them at scale still doesnt exist

EMT is characterized by the downregulation of cell-cell adhesion molecules, including E-cadherin, and the upregulation of mesenchymal markers, such as SMA, fibroblast-specific protein 1 (FSP1), fibronectin, collagen, and vimentin (70)

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This triggers collagen synthesis , attracts immune cells, promotes blood vessel formation, and activates dozens of genes involved in tissue repair