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tBOOH induces disorganization of the tight-junctional complex in hepatocyte couplets, as suggested by the redistribution of the tight-junctional-associated protein, ZO-1.98 Changes in ZO-1 localization are however not observed in isolated perfused rat livers exposed to tBOOH, suggesting that the couplet model is a more sensitive model to study associations between functional and structural changes of the tight-junctional barrier

[DOI] [PubMed] [Google Scholar] 23.Zhao P, Slattery JT

Elevated serum B12 levels may indicate underlying conditions such as liver disease, kidney dysfunction, or myeloproliferative disorders requiring medical evaluation